The growth rate of the atmospheric abundance of methane (CH 4) reached a record high of 15.4 ppb yr −1 between 2020 and 2022, but the mechanisms driving the accelerated CH 4 growth have so far been ...

As former EPA and ORD scientists, we argue that dismantling ORD would not only jeopardize human and environmental health, but also weaken American science and global competitiveness. ORD’s vital—yet ...

Sorting cells with target metabolic functions from a mutant pool exhibiting substantial genetic diversity is often the rate-limiting step in synthetic biology. Here, we developed a label-free, ...

The synthesis of new polyhydrides with high superconducting Tc is challenging owing to the high pressures and temperatures required. In this study, we used machine-learning potential molecular ...

Natural ice plays salient roles in making the Earth habitable and sustainable. Previously overlooked, its role in chemical processes is now of emerging interest, particularly due to the freeze ...

The prostaglandin D2 receptor (DP1) functions as a critical regulator of diverse physiological processes, including sleep–wake cycles, allergic responses, and inflammatory cascades. By determining ...

Greening immediately after etiolated-seedling’s emergence from the soil is critical for plants to initiate their autotrophic life cycle through photosynthesis. The greening process relies on a complex ...

Self-reproduction is one of the most fundamental features of natural life. This study introduces a biochemistry-free method for creating self-reproducing polymeric vesicles. In this process, ...

GAK and its chaperone protein, Hsc70, are known to be recruited to clathrin-coated vesicles (CCVs) to mediate clathrin uncoating. Previous studies have proposed that early recruitment of GAK–Hsc70 to ...

Calcineurin is a highly conserved phosphatase that plays a central role in sensing calcium and governing transcriptional, posttranscriptional, and posttranslational signaling networks. Calcineurin is ...

Scientists have long promised that AI will make more rational decisions than even expert humans. These studies show that this is not a foregone conclusion because large language models (LLMs) already ...

Currently, various tools are available for studying intraorganellar calcium activity, such as genetically encoded calcium indicators (GECIs) specifically targeted to the lumens of organelles. However, ...