The EMBO Journal7h
Acquired resistance to PD-L1 inhibition enhances a type I IFN-regulated secretory program in tumors
Acquired resistance to PD-L1 inhibition can rewire the interferon-regulated secretory machinery in tumor cells, altering the ...
The EMBO Journal6d
Histone methyltransferases MLL2 and SETD1A/B play distinct roles in H3K4me3 deposition during the transition from totipotency to pluripotency
In early mammalian embryogenesis, a shift from non-canonical histone H3 lysine 4 trimethylation (H3K4me3) linked to transcriptional repression to canonical H3K4me3 indicating active promoters occurs ...
The EMBO Journal7d
Kinesin-like motor protein KIF23 maintains neural stem and progenitor cell pools in the developing cortex
The kinesin-like motor protein KIF23 is a critical component of the mitotic central spindle. This study uncovers a role of ...
The EMBO Journal7d
How J-chain ensures the assembly of immunoglobulin IgM pentamers
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Polymeric IgM immunoglobulins have high ...
The EMBO Journal7d
Rarγ-Foxa1 signaling promotes luminal identity in prostate progenitors and is disrupted in prostate cancer
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Retinoic acid (RA) signaling is a master ...
The EMBO Journal7d
Mitochondrial calcium uniporter complex controls T-cell-mediated immune responses
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. MCU plays a key role in controlling ...
The EMBO Journal8d
Targeting to BMP9 to restrain flare-up of fibrodysplasia ossificans progressiva
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized primarily by the formation of heterotopic ...
The EMBO Journal8d
Tubulin glutamylation regulates axon guidance via the selective tuning of microtubule-severing enzymes
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The microtubule cytoskeleton is a major ...