Mutations in NPC1 cause Niemann-Pick Type C. Mice lacking NPC1 only in microglia have rampant neuroinflammation and impaired ...

Some drugs can activate AMPK, most prominently metformin, which is approved for diabetes and being trialed in dementia. Less well-known is aldometanib, developed by Lin’s team, which blocks aldolase, ...

The first round of a debate is most useful for isolating the crux. I therefore kindly ask for one more public round. This would be most beneficial, not just for me, but also for the many Alzforum ...

Gut-Brain Connection. People who have CD83+ microglia in their brains also have HCMV (top left) and IgG4 (top right) in their ...