Buffalo Bills wide receiver Mack Hollins, middle left, scores a touchdown past San Francisco 49ers cornerback Charvarius Ward ...

The Buffalo Bills dominated the San Francisco 49ers on Sunday night, winning 35-10 in Highmark Stadium in Orchard Park, N.Y.

Running away with the AFC East: For the fifth consecutive season, the Bills are AFC East champions. This season was ...

ORCHARD PARK, NEW YORK - DECEMBER 01: Josh Allen #17 of the Buffalo Bills and head coach Sean McDermott make snow angels ...

The Philadelphia Eagles will face off against the Baltimore Ravens in Week 13 of the NFL season on Sunday. This prediction ...

Despite playing sparingly in previous weeks, Elijah Fuentes-Cundiff likely played his best game of the year against Miami ...

Syracuse Orange center Izabel Varejao (34) runs baseline past Talya Brugler (0) of Saint Joseph’s . The Syracuse Orange Women ...

Orchard Park, N.Y. — You may have caught a glimpse of Buffalo Bills offensive lineman Alec Anderson during the celebration of James Cook’s 65-yard touchdown that opened the floodgates of scoring ...

Zetagen Therapeutics is staking its future on results it obtained in helping a Florida woman cope with Stage 4 breast cancer.

DEAR ABBY: My husband and I have been married for 15 years. He made a resolution to go on a diet and cut out sweets. However, ...

Philadelphia Eagles running back Saquan Barkley had another stellar outing in Sunday’s big win over the Baltimore Ravens. The ...

The latest forecast this morning for kickoff at 8:20 p.m. today calls for a temperature of 26 degrees and a wind chill of 16 ...