San Francisco 49ers quarterback Brock Purdy is expected to return to the field on Sunday against the Buffalo Bills after ...

Running back Christian McCaffrey says the San Francisco 49ers are "hungry" to make a playoff push even with the defending NFC ...

A light dusting of snow began covering the Buffalo Bills' facility on Friday as the team completed its final practice of the ...

The San Francisco 49ers have released their final injury report ahead of their Week 13 bout with the Buffalo Bills.

Preview the Week 13 matchup between the Buffalo Bills and San Francisco 49ers with predictions, odds, over/under, spread, ...

The San Francisco 49ers expect to get quarterback Brock Purdy back for their Week 13 matchup with the Buffalo Bills. That’s ...

The Buffalo Bills will look to lock up a playoff spot in their Week 13 showdown with the San Francisco 49ers. Here are five ...

One thing does not change, though. The defending NFC champion 49ers are 5-6 and they need to get on a heater - which will be ...

A good ol' fashioned lake effect snowstorm is burying western New York this weekend when the Buffalo Bills and San Francisco ...

Matt Eberflus is still the head coach of the Chicago Bears and he's confident that won't change going into next week's game ...

If the 49ers can't break out of their funk, here are three maneuvers they should consider down the home stretch.