After sparking the 49ers with a handful of impressive runs, Christian McCaffrey looked like himself early in the game against ...

Fantasy football analyst Matt Harmon delivers his thoughts on the major happenings of Week 13's Sunday action.

According to head coach Kyle Shanahan, running back Christian McCaffrey suffered a potentially season-ending PCL injury in their 35–10 loss against the Buffalo Bills.

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

The swagger is officially gone from this season's 49ers after another miserable outing in a 35-10 loss in Buffalo.

On a snowy night in Orchard Park, N.Y., the Buffalo Bills clinched the AFC East title with a dominant win over the San ...

Christian McCaffrey was having a resurgent game against the Buffalo Bills. He finally looked like the player who was supposed ...

Christian McCaffrey pulled up limping after taking a pitch early in their game against the Bills on Sunday night.

San Francisco 49ers running back Christian McCaffrey was running wild against the Buffalo Bills on Sunday Night Football.

The 49ers season is still trending down and now they're searching for answers on if they can get back on track.

Dec 1, 2024; Orchard Park, New York, USA; San Francisco 49ers running back Christian McCaffrey (23) tries to avoid Buffalo ...

Josh Allen and Buffalo are quickly emerging as Super Bowl favorites after delivering another stellar performance on Sunday ...