Fantasy football analyst Matt Harmon delivers his thoughts on the major happenings of Week 13's Sunday action.

According to head coach Kyle Shanahan, running back Christian McCaffrey suffered a potentially season-ending PCL injury in their 35–10 loss against the Buffalo Bills.

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

Christian McCaffrey's injury appeared to happen with 12:58 left in ... that are already doing it or new guys who are getting ...

On a snowy night in Orchard Park, N.Y., the Buffalo Bills clinched the AFC East title with a dominant win over the San ...

The 49ers season is still trending down and now they're searching for answers on if they can get back on track.

Josh Allen and Buffalo are quickly emerging as Super Bowl favorites after delivering another stellar performance on Sunday ...

San Francisco coach Kyle Shanahan told reporters postgame that their star running back had injured the posterior cruciate ...

Josh Allen scored a receiving touchdown on a pass he threw in his latest do-everything performance, and the Buffalo Bills ...

San Francisco 49ers running back Christian McCaffrey left Sunday night's contest versus the Buffalo Bills with what the team ...

Buffalo was a perfect 4-for-4 in the red zone. A big factor in the Bills' success was their run game. RB James Cook had 14 ...

McCaffrey left Sunday’s blowout loss in Buffalo with a knee injury, and Kyle Shanahan was quick to rule him out.