S&P 500 and Nasdaq futures are falling in premarket trading. The Dow is flat ahead of Fed Chair Jerome Powell's Speech at Jackson Hole.

Powell's speech at Jackson Hole will set the tone for policy through the rest of this year. BofA says the speech will drive big swings in these stocks.

NEW YORK (AP) — U.S. stock indexes are edging lower on Thursday as Wall Street makes its final moves before the head of the Federal Reserve gives a highly anticipated speech on Friday that could hint at where interest rates are going.

Live Updates Live Coverage Has Ended Thursday Wrap-up 4:17 pm The Vanguard S&P 500 ETF closed at 584.27 Thursday, down 0.4%. Morgan Stanley Loves HP Enterprise 12:31 pm In analyst action, Morgan Stanley analyst Erik Woodring upgraded shares of HP Enterprise (NYSE: HPE) to overweight with a $28 price target this morning.

When Nvidia, the chip producer, reports earnings next week, investors expect the S&P 500 to have a bigger reaction than when the Fed chair delivers a big speech on Friday.

Stocks might get their September interest-rate cut, but the Federal Reserve could still disappoint the market, as soon as this month.

Shares of business intelligence platform Domo (NASDAQ:DOMO) fell 4.6% in the pre-market session after a broader market downturn impacted the technology sector, as investors grew cautious ahead of a key speech by Federal Reserve Chair Jerome Powell.

Among the Nasdaq 100 stocks, Analog Devices ADI and Palo Alto Networks PANW rallied 3.7% and 1.6%, respectively, making them some of the best performers at the market open. On the downside, Intel INTC and Micron Technology MU tumbled 4.1% and 3.6%, respectively.