After sparking the 49ers with a handful of impressive runs, Christian McCaffrey looked like himself early in the game against ...

The Week 13 Sunday slate closes with the Buffalo Bills (9-2) hosting the San Francisco 49ers (5-6) on Sunday Night Football.

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

Former Wisconsin running back Isaac Guerendo scored the second touchdown of his young NFL career in the San Francisco 49ers’ ...

The San Francisco 49ers running back has sustained a posterior cruciate ligament (PCL) injury, head coach Kyle Shanahan ...

If you had on your bingo card Buffalo Bills coach Sean McDermott laying down on the snow covered turf at Highmark Stadium doing snow angels next to quarterback Josh Allen late Sunday night, well bolly ...

Tonight the Buffalo Bills will proceed with playing the San Francisco 49ers at 8:20 p.m. Orchard Park already had 22.9 inches ...

Two sides stuck on losing streaks meet at the Levi's Stadium in Game Week 14.  The Buffalo Bills comfortably beat the 49ers ...

The Buffalo Bills won against the San Francisco 49ers with a 35-10 score in a snowy Sunday Night Football game. Josh Allen ...

Josh Allen became the first quarterback since 1970 to score a rushing touchdown, pass for a touchdown and have a scoring ...

Christian McCaffrey has barely played this season. But the star running back could already be done for the year. On a snowy ...

Russell Wilson and the Steelers are on the rise after another key win, as the 49ers continue to tumble. Who else won or lost ...