Running back Christian McCaffrey is on injured reserve for the second time this season, but San Francisco 49ers coach Kyle ...

Christian McCaffrey's injury-ridden season took another unfortunate turn when the star running back went down with another ...

Following their win over the San Francisco 49ers, the Bills (10-2) will take on the Los Angeles Rams (6-6) at SoFi Stadium in ...

The 49ers superstar made the statement in a lengthy caption on his Instagram fee after the team put him on injured reserve ...

Kyle Shanahan explains why 49ers rookie Isaac Guerendo is ready to be the starter with Christian McCaffrey and Jordan Mason out.

San Francisco 49ers running back Christian McCaffrey made his season debut less than one month ago after missing the first ...

BUFFALO, N.Y. (WKBW) — For the second time this season and the 14th time in his career, Buffalo Bills quarterback Josh Allen ...

The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve for the second time this season after ...

Head coach Kyle Shanahan reflected on the team's performance against the Bills, previewed the upcoming Week 14 matchup ...

An Arctic cold front will bring intense snow squalls, strong winds and heavy lake-effect snow to parts of the Northeast, ...

Nick Bosa is one of several San Francisco 49ers players who will not participate in practice on Wednesday as the team begins ...