The San Francisco 49ers' losses to the Green Bay Packers and Buffalo Bills mark the worst two-game stretch by a defending ...

The 49ers just lost 35-10 to the Buffalo Bills. Now the 49ers are 5-7 and all alone in last place in the NFL West. Here are ...

The San Francisco 49ers suffered another crushing defeat Sunday night, falling 35-10 to the Buffalo Bills. The loss marked ...

Josh Allen scored a receiving touchdown on a pass he threw in his latest do-everything performance, and the Buffalo Bills ...

Before the 2024 NFL season, Sunday night's Week 13 matchup between the Buffalo Bills and San Francisco 49ers might've been ...

Buffalo Bills outside linebacker Greg Rousseau chases down San Francisco 49ers quarterback Brock Purdy to boosts his 2024 NFL ...

After three strong weeks of play from 49ers RB Christian McCaffrey, he left the game against the Bills after suffering a knee ...

Christian McCaffrey is dealing with an injury again. The 49ers running back went down with a knee injury in the second ...

Brandon Allen is 2-8 in 10 career starts. One of them was against Josh Allen and the Bills but Brandon Allen wore No. 2 in ...

The 49ers decide whether or not to play quarterback Brock Purdy, dealing with injury, for Week 13 against the Bills on Sunday ...

Check out who's in and who's out for Week 13. Plus weather reports, last-minute free agency options, and Jake Ciely's fantasy ...

The 49ers' other inactives are defensive linemen Nick Bosa (hip, oblique) and Jordan Elliott (concussion), cornerback ...