Defensively, two of the 49ers’ best players this season are out and will not travel as defensive end Nick Bosa (obliques, ...

Brock Purdy speaks with reporters ahead of San Francisco's Week 13 matchup against the Buffalo Bills on Sunday night.49ers QB ...

Heavy snow is expected in Erie County, New York, this weekend, including Sunday night when the AFC East-leading Bills host ...

SANTA CLARA — It’s not like he was throwing at game speed, but the sight of Brock Purdy throwing the ball during warmups ...

The San Francisco 49ers have released their final injury report ahead of their Week 13 bout with the Buffalo Bills.

San Francisco 49ers quarterback Brock Purdy is expected to return to the field on Sunday against the Buffalo Bills after ...

Purdy missed the 49ers' Week 12 contest versus the Green Bay Packers last Sunday with a right shoulder injury—a game San ...

One thing does not change, though. The defending NFC champion 49ers are 5-6 and they need to get on a heater - which will be ...

Running back Christian McCaffrey says the San Francisco 49ers are "hungry" to make a playoff push even with the defending NFC ...

A light dusting of snow began covering the Buffalo Bills' facility on Friday as the team completed its final practice of the ...

Buffalo Bills coach Sean McDermott ruled out Dalton Kincaid from playing against San Francisco on Sunday night, while holding ...