Phase 1 Data Indicate Potential for Use of Once-Yearly Lenacapavir for HIV Prevention, with Plans to Launch a Phase 3 Trial in 2H 2025 – ...

Transposons, also known as jumping genes or mobile genetic elements, can replicate and reintegrate themselves into the genome, posing a threat to genomic integrity by inducing DNA rearrangements and ...

Merck Sharp & Dohme LLC has synthesized viral replication inhibitors reported to be useful for the treatment of respiratory syncytial virus and metapneumovirus infections.

The study, published in Cell today, reveals how the retrotransposon copia completes its replication cycle and travels into the nucleus through the nuclear pores. The study is a collaboration between ...

We detected neither viral envelope nor replication-competent retroviruses in transduced CD34 + cells before infusion or in any samples obtained after transplantation. We have used both enzyme ...

The complex retroviruses, such as HIV, encode additional trans-regulating factors or contain cis-regulating elements, thereby influencing the type and amount of transcribed RNA. The whole viral ...

In keeping with recent conferences, several studies of investigational agents, some of them near approval and some in the earliest phases of development, were presented. This summary focuses on ...

Human endogenous retroviruses (HERVs) are derived from the infection and integration of exogenetic retroviruses. HERVs account for 8% of human genome, and the majority of HERVs are solitary LTRs (solo ...

However, they were uncertain about how HIV controls the remodeling of the cell membrane as it exits the cells and what role the lipid envelope plays in HIV replication. “Viruses in general, because ...

HERVs, or human endogenous retroviruses, make up around 8% of the human genome, left behind as a result of infections that humanity’s primate ancestors suffered millions of years ago. They became part ...

For example, during primary infection, infected monocytes migrate into tissues and differentiate into macrophages, which then become a source of viral replication. In addition, because differentiated ...

1 Institut de Génétique Moléculaire, UMR5535, CNRS, UMII, 1919, Rte de Mende, 34293 Montpellier and 2 Department of ‘Infections Rétrovirales et Signalisation Cellulaire’, UMR5121 CNRS, UMI 4 Boulevard ...