One thing does not change, though. The defending NFC champion 49ers are 5-6 and they need to get on a heater - which will be tough to do Sunday night in Buffalo - if they stand any chance of defending their crown because right now they’re in last place in the NFC West and sitting outside the NFC wild-card picture.

Colin Cowherd believes that the Buffalo Bills are the best team in the NFL when playing at full strength. Somebody forgot to tell members of the Buffalo Bills’ locker room that 2024 was supposed to be a rebuilding year.

San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got destroyed by the Green Bay Packers. Granted Brock Purdy didn't play, but the 49ers didn't look like an NFC contender.

Three teams face playoff-clinching scenarios in Week 13. Here's what the Bills, Lions and Chiefs need to earn a playoff berth.

The Buffalo Bills are on a fast track to win the AFC East championship and clinch a playoff spot. But that won't happen in Week 12 of the NFL season. After beating the reigning Super Bowl champions Sunday, the Bills are at 9-2. The last time the team had ...

As of Nov. 27, the Buffalo Bills' odds of winning the Super Bowl (+750) make them fourth-best in the league. In their last game on Nov. 17, the Bills took home a 30-21 win against the Kansas City ...

After its Week 11 party in Buffalo, "The NFL Today" crew is hitting the road again. This time, the NFL on CBS pregame show will broadcast live from Ford Field in anticipation of the Detroit Lions' Week 15 matchup against Josh Allen and the Buffalo Bills.

There is a high Risk of Weather Impact (ROWI) for the NFL's Sunday Night Football matchup between the 49ers (5-6) and the Bills (9-2) in Buffalo.

The Bills designated Carter (wrist) for return from injured reserve Wednesday, Alaina Getzenberg of ESPN.com reports. A third-round pick at No. 95 overall out of Duke in the 2024 NFL Draft ...

Josh Allen is getting his ring. The Buffalo Bills quarterback is trying to lead his team to a first-ever Super Bowl title but added some personal hardware this week. Allen took to Instagram to announce that he had girlfriend Hailee Steinfeld had gotten ...

The San Francisco 49ers could have Brock Purdy back soon, as the quarterback was recently seen throwing passes in a video after being limited in practice just a few days ago due to injury concerns. Brock Purdy could return to the starting role for the San Francisco 49ers in Week 13 against the Buffalo Bills on the road.