San Francisco fumbled the ball three times and lost all three. Brock Purdy dropped back to pass 20 times for 86 net yards.

After U.S. travelers battled through harsh weekend weather to reach home following the Thanksgiving holiday, forecasters say ...

On a snowy night in Orchard Park, N.Y., the Buffalo Bills clinched the AFC East title with a dominant win over the San ...

A picturesque setting of snow was the perfect backdrop for a Buffalo Bills team that has now won its fifth straight AFC East ...

For the fifth straight season, Buffalo will host a home playoff game after their impressive victory in the snow Sunday night.

The Buffalo Bills have secured their fifth straight AFC East title thanks to their Week 13 win over the San Francisco 49ers.

A Buffalo Bills fan seemingly tried to use the snowy weather to their advantage on Sunday night as they appeared to toss a ...

Kyle Shanahan said McCaffrey is believed to have injured his posterior cruciate ligament, which connects the thigh bone to ...

One week after a 38-10 road loss to the Green Bay Packers that stood out as one of their ugliest defeats in years, the San ...

Buffalo Bills tight end Dawson Knox takes San Francisco 49ers safety Ji'Ayir Brown for a ride on a 39-yard catch and run.

Taylor Rapp punches the ball out of Kyle Juszczyk’s hands near the goal line, where Christian Benford picks it up and runs it ...

The San Francisco 49ers have released the list of inactive players for their Week 13 matchup against the Buffalo Bills. These ...