A replication-competent adenovirus with tumor specificity was constructed by replacing the endogenous E1A promoter with a human telomerase reverse transcriptase promoter (TERTp) to control the ...

Such vaccines have the potential to provide full protection from influenza infection by inhibiting viral replication. Adenovirus-based SARS-CoV-2 vaccine.

The replication of potentially harmful adenoviruses can be significantly reduced in human cells in cell culture by using the so-called CRISPR-Cas9 system ("gene scissors"). This method, which is ...

Replication of ONYX-015 and wild-type Ad2 adenovirus in A2780 and drug-resistant derivatives. The human ovarian cell line A2780, derived from an untreated patient, has wild-type p53 sequence and ...

Brazil’s regulators say they reviewed data indicating that there was replication-competent adenovirus (RCA) in every evaluated batch of the second Ad5-based dose of Sputnik V.

The vaccine is made up of two types of adenovirus. For one, a justification is presented for non-replication; for the other, it is not,” Mendes said. Meeting with Gamaleya Institute ...

The adenovirus helper plasmid provides essential helper functions for AAV replication and packaging, whereas the AAV genome plasmid contains the therapeutic gene flanked by inverted terminal ...

Unlike the other two already approved in the U.S., the Pfizer and Moderna vaccines, the J&J "Janssen adenovirus-replication-deficient COVID-19 vaccine" only take one shot to gain effectiveness at ...

Because the adenovirus proteins involved in genome replication are distinct from those involved in particle assembly and genome packaging, the researchers reasoned focusing on this virus would ...

Adenovirus Replication Research (IMAGE) Saint Louis University. Caption. William Wold, Ph.D., is chair of molecular microbiology and immunology at Saint Louis University and senior author on ...