Overdiagnosis has been described as ‘unwarranted diagnosis’ (Moynihan et al, 2018). It is the formulation and conveyance of a label –generally of a disease or condition - that can lead to patient harm ...

Scientific progress, including in evidence-based medicine, requires all available evidence to be accessed, scrutinised, interpreted and used. Missing or incomplete evidence creates biases and errors ...

Breast density is one of a number of independent risk factors for breast cancer.1 Having dense breasts (heterogeneously dense or extremely dense) is prevalent in 40%–50% of women in the breast ...

After conducting a database search, the subsequent phase in the execution of systematic reviews (SRs) involves title and abstract screening.1 This stage bears significant importance and necessitates ...

Tricyclic antidepressants reduce frequency of tension-type and migraine headaches compared with placebo, and intensity of headaches compared with SSRIs, but cause greater adverse effects ...

Objectives To determine the barriers and facilitators to using real world data (RWD) in healthcare settings in low-and middle-income countries (LMICs). Method We conducted a systematic review through ...

Changing disease or health risk definitions and labels where there is a case for no or little net benefit and significant harm, has the potential to affect millions of people worldwide. It appears, on ...