Running back Christian McCaffrey says the San Francisco 49ers are "hungry" to make a playoff push even with the defending NFC ...

In January, a lake-effect storm forced the NFL to push back the Bills' wild-card playoff home game against Pittsburgh by a ...

Up to three feet of snow could batter the Buffalo Bills’ stadium this weekend, where the San Francisco 49ers are scheduled to ...

The San Francisco 49ers have released their final injury report ahead of their Week 13 bout with the Buffalo Bills.

One thing does not change, though. The defending NFC champion 49ers are 5-6 and they need to get on a heater - which will be ...

A good ol' fashioned lake effect snowstorm is burying western New York this weekend when the Buffalo Bills and San Francisco ...

Purdy missed the 49ers' Week 12 contest versus the Green Bay Packers last Sunday with a right shoulder injury—a game San ...

Buffalo Bills coach Sean McDermott ruled out Dalton Kincaid from playing against San Francisco on Sunday night, while holding ...

Bonnie is a sweet cattle dog mix and she knows how to get a team moving! Watch as she makes her choice on the Bills vs 49ers ...

The Buffalo Bills have the chance to make team history on "Sunday Night Football" against the San Francisco 49ers.

San Francisco 49ers quarterback Brock Purdy is poised to return to action on Sunday night against the Buffalo Bills after ...