Following a brutal 38-10 loss to the Green Bay Packers last week, things didn't get any easier for the San Francisco 49ers ...

The Week 13 Sunday slate closes with the Buffalo Bills (9-2) hosting the San Francisco 49ers (5-6) on Sunday Night Football.

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

Two sides stuck on losing streaks meet at the Levi's Stadium in Game Week 14.  The Buffalo Bills comfortably beat the 49ers ...

Tonight the Buffalo Bills will proceed with playing the San Francisco 49ers at 8:20 p.m. Orchard Park already had 22.9 inches ...

If you had on your bingo card Buffalo Bills coach Sean McDermott laying down on the snow covered turf at Highmark Stadium doing snow angels next to quarterback Josh Allen late Sunday night, well bolly ...

The San Francisco 49ers running back has sustained a posterior cruciate ligament (PCL) injury, head coach Kyle Shanahan ...

Josh Allen became the first quarterback since 1970 to score a rushing touchdown, pass for a touchdown and have a scoring ...

Russell Wilson and the Steelers are on the rise after another key win, as the 49ers continue to tumble. Who else won or lost ...

Josh Allen scored one of the more remarkable touchdowns of this — or any — season Sunday night in Buffalo's 35-10 blowout of ...

The Great Lakes region is seeing new snow and faces the prospect of even more this week after U.S. travelers battled harsh weather to get home after Thanksgiving ...

The Buffalo Bills confirmed their fifth AFC top-spot in a row with a victory over the San Franciso 49ers and head to LA in ...