Providing the betting odds and our preview and prediction for the star-studded matchup between the San Francisco 49ers and ...

In a season where running backs are thriving in the NFL, the 49ers hope to get Christian McCaffrey back on track.

The San Francisco 49ers didn’t have many changes to their Thursday practice participation report.

Speaking with reporters on Wednesday, San Francisco 49ers head coach Kyle Shanahan says it's "unfair" to expect running back ...

Christian McCaffrey has been inefficient in his three games played since dealing with Achilles tendinitis. He doesn't look ...

Christian McCaffrey is averaging a mere 3.5 yards per carry this season since he returned from bilateral Achilles tendonitis.

San Francisco 49ers running back Christian McCaffrey is three games into his return from injury. The two-time first-team ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night.

Brock Purdy threw one short pass in the open portion of practice for the San Francisco 49ers as he remains slowed by an ...

San Francisco 49ers quarterback Brock Purdy was limited with the right shoulder injury that sidelined him last week and there ...

Renee Miller equates players to Thanksgiving foods — savory or unsavory — to help you get set for the holiday weekend.

Even after Christian McCaffrey’s return to the field, the story surrounding his Achilles injury and the impact it’s having on ...