Head coach Kyle Shanahan shared the final injury report on QB Brock Purdy, DL Nick Bosa and others and discussed the team's ...

Running back Christian McCaffrey refuses to buy into the doom and gloom surrounding the San Francisco 49ers since two ...

The AFC East-leading Buffalo Bills return from their bye week to host the inconsistent San Francisco 49ers on Sunday night ...

Providing the betting odds and our preview and prediction for the star-studded matchup between the San Francisco 49ers and ...

Watch Matt Maiocco's full "Game Plan" interview with John Lynch at 9:30 p.m. PT Friday on NBC Sports Bay Area. SANTA CLARA — ...

One thing does not change, though. The defending NFC champion 49ers are 5-6 and they need to get on a heater - which will be ...

Building winning Fantasy football picks requires a full understanding of Fantasy football injuries and Fantasy football ...

The San Francisco 49ers are up against the Buffalo Bills in Week 13. The 49ers have dealt with an array of injuries this ...

San Francisco 49ers head coach Kyle Shanahan was strong in defending Christian McCaffrey from criticism following his poor ...

The 49ers’ situation could grow even more dire if Brock Purdy isn’t ready for Sunday’s must-win matchup against the Buffalo ...

In a season where running backs are thriving in the NFL, the 49ers hope to get Christian McCaffrey back on track.