San Francisco 49ers quarterback Brock Purdy is expected to return Sunday against the Buffalo Bills, head coach Kyle Shanahan ...

Running back Christian McCaffrey refuses to buy into the doom and gloom surrounding the San Francisco 49ers since two straight losses sent them below .500. “I think the vibe is probably a lot lower ...

One thing does not change, though. The defending NFC champion 49ers are 5-6 and they need to get on a heater - which will be ...

Simpson carried the ball 29 times against the Lions and set a new NFL record with 273 rushing yards, breaking his own record ...

Before you make any Week 13 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen.

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According to Travis Kelce's brother, Jason Kelce, not too many folks thought that the ball would end up in Allen's hands at ...

Patrick Mahomes was fined nearly $15,000 for a 'violent' hand gesture he made during the Kansas City Chiefs' game against the ...

Kansas City Chiefs quarterback Patrick Mahomes was reportedly fined by the NFL over the weekend for unsportsmanlike conduct ...

San Francisco has put up a combined 27 points the past two weeks and faces a Bills defense great at generating pressure with ...

SportsLine's advanced model has locked in its Week 13 NFL betting picks and football predictions from 10,000 simulations to ...

With the calendar turning over to December, these are the numbers to know with the 49ers needing a win: 6.3 The Bills offense ...