San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

Lake-effect snow has been hitting Buffalo throughout the holiday weekend with is expected to continue off and on through ...

Quarterback Brock Purdy did not waste any time in getting the ball into the hands of 49ers tight end George Kittle on Sunday.

The Bills are coming off a bye week and riding a six-game winning streak behind MVP favorite Josh Allen, most recently ...

The San Francisco 49ers suffered another crushing defeat Sunday night, falling 35-10 to the Buffalo Bills. The loss marked ...

The 49ers just lost 35-10 to the Buffalo Bills. Now the 49ers are 5-7 and all alone in last place in the NFL West. Here are ...

Josh Allen scored a receiving touchdown on a pass he threw in his latest do-everything performance, and the Buffalo Bills ...

San Francisco 49ers quarterback Brock Purdy is poised to return to action on Sunday night against the Buffalo Bills after ...

San Francisco 49ers star running back Christian McCaffrey departed Sunday night's snow game against the Buffalo Bills early ...

Buffalo Bills outside linebacker Greg Rousseau chases down San Francisco 49ers quarterback Brock Purdy to boosts his 2024 NFL ...

Follow along for updates throughout the game as the Buffalo Bills take on the San Francisco 49ers at snowy Highmark Stadium.

Brandon Allen is 2-8 in 10 career starts. One of them was against Josh Allen and the Bills but Brandon Allen wore No. 2 in ...