In adults with influenza A (H1N1) or (H3N2) virus infection, the development of resistance to oseltamivir is rare, but resistant viral variants have been detected in up to 18 percent of children ...

A 2004 study in Japan found that 9 of 50 children with influenza A (H3N2) virus infection who had been treated with oseltamivir (18 percent) had a virus with a drug-resistance mutation in the ...

Resistance to oseltamivir was identified among 142 of 1,155 U.S. influenza A(H1N1) viruses (12 percent) tested during the 2007-2008 influenza season.

Oseltamivir resistance can be conferred by a single point missense mutation from histidine to tyrosine at position 275 (H275Y) of the neuraminidase gene, which is the most commonly reported mutation.

Transmissibility and pathogenicity of resistant strains appear similar to those of susceptible strains. In 2006, the circulating influenza A virus rapidly became resistant to the adamantanes ...

Their lab experiments, published in March, found the two mutations appeared to raise H1N1's resistance to the flu treatment oseltamivir, commonly sold under the brand Tamiflu by drugmaker Roche.

To date, all but one of these oseltamivir-resistant strains of pandemic H1N1 have been found to have the H275Y mutation. Resistance is infrequent and detected sporadically in pandemic H1N1, although ...

Clinical evidence of oseltamivir (Tamiflu, Roche) resistance has been confirmed in patients infected with the novel avian H7N9 flu, as published online in The Lancet.

New findings indicate the emergence of oseltamivir-resistant 2009 H1N1 virus in England and Scotland — particularly among immunocompromised patients. Laurence Calatayud, MD,trainee of the ...

Should seasonal flu, H5N1, or any other variant develop resistance to oseltamivir and baloxavir, providers and their patients would have extremely limited options. “Suffice it to say that we ...

Resistance to oseltamivir was identified among 142 of 1,155 U.S. influenza A(H1N1) viruses (12 percent) tested during the 2007-2008 influenza season.

Influenza continues to pose a significant global health burden, with seasonal outbreaks causing substantial morbidity and ...