Bills vs 49ers prediction, keys to Sunday Night Football game that may be played in snow
One thing does not change, though. The defending NFC champion 49ers are 5-6 and they need to get on a heater - which will be tough to do Sunday night in Buffalo - if they stand any chance of defending their crown because right now they’re in last place in the NFC West and sitting outside the NFC wild-card picture.
Early 49ers vs Bills Predictions, Picks, and Odds for SNF Week 13
San Francisco has put up a combined 27 points the past two weeks and faces a Bills defense great at generating pressure with just the front four. Buffalo is Top 10 in EPA allowed per pay and very stingy against the run, sitting seventh in run-stop win rate at ESPN and No. 9 in opponent success rate per handoff.
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Before you make any Week 13 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen.
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