This problem can be partially remedied by using adenoviruses that have been genetically modified to be temperature-sensitive or replication-defective. AAV is not exclusively reliant on adenovirus ...

Adenoviral vectors will transduce a wide range of target cells resulting in high-level gene expression. They are non-integrating vectors so expression in dividing cells is progressively lost. First ...

One of the central challenges of rAAV production is the need for a ‘helper virus’ to facilitate replication within ... would first be infected with adenovirus, after which they would be ...