Head coach Kyle Shananhan said running back Christian McCaffrey suffered a knee injury during the team's 35-10 loss to the ...

Before the 2024 NFL season, Sunday night's Week 13 matchup between the Buffalo Bills and San Francisco 49ers might've been ...

In eight season’s San Francisco 49ers tight end George Kittle never played in Buffalo at Highmark Stadium. Despite the loss ...

The San Francisco WAG All-Star has fun and looks good in the snow on Sunday night, but she’s ready to burn her creation.

During the San Francisco 49ers 35-10 loss to the Buffalo Bills on Sunday night, superstar running back Christian McCaffrey ...

San Francisco 49ers tight end George Kittle told reporters he had "no idea" why he received just two targets during a 35-10 ...

NFL Week 14 odds, picks, predictions, TV channel, streaming information for Sunday football game between Chicago Bears and ...

The San Francisco 49ers may soon lose one of their best offensive players to the Minnesota Vikings in free agency.

Josh Allen expertly navigated snow-topped turf, finding the end zone in a multitude of fashions and even receiving credit for ...

San Francisco 49ers star running back Christian McCaffrey's season is in jeopardy after he sustained what is believed to be a ...

The Buffalo Bills beat the San Francisco 49ers 35-10 in a game that was dominated by Josh Allen. Craig Carton, Danny Parkins, ...

With its 35-10 loss at Buffalo on Sunday night, the 49ers have now dropped three straight to sink to 5-7 on the season. The ...