Running back Christian McCaffrey says the San Francisco 49ers are "hungry" to make a playoff push even with the defending NFC champions sitting at 5-6.

One thing does not change, though. The defending NFC champion 49ers are 5-6 and they need to get on a heater - which will be tough to do Sunday night in Buffalo - if they stand any chance of defending their crown because right now they’re in last place in the NFC West and sitting outside the NFC wild-card picture.

The San Francisco 49ers are preparing for a business trip to western New York for a massive obstacle in the way of the 9-2 Buffalo Bills. The 49ers are in a tight battle for the NFC West, with all four teams within one game of each in the standings.

The San Francisco 49ers have released their final injury report ahead of their Week 13 bout with the Buffalo Bills.

San Francisco 49ers quarterback Brock Purdy is listed as questionable for Sunday's game against the Buffalo Bills, but he fully participated in practice this week, which can be seen as a positive sign that he'll be ready to play, per Tom Pelissero.

Brock Purdy is expected to return Sunday night against the Bills, but offensive tackle Trent Williams, defensive end Nick Bosa and cornerback Deommodore Lenoir have been ruled out.