Two short weeks after losing by 54 points in Boston, the Toronto Raptors handed the Celtics their most humbling loss of the season.

RJ Barrett had 22 points and 10 rebounds, and the Toronto Raptors snapped a 10-game losing streak against Boston with a 110-97 victory over the Celtics.

Payton Pritchard had 20 points to lead the Celtics. Jayson Tatum had just 16 points and Jaylen Brown had 10, with the All-Star duo combining to make just 9 of 31 shots.

Toronto came into tonight's action ranked third in fast break points in the NBA, while Boston is dead last in that regard. In indeed, the Raptors scored 18 points in transition, taking advantage of some sluggish defense on the part of the Celtics. Boston scored just 5 going the other way.

The Toronto Raptors pulled off the biggest upset of the season by knocking off the Boston Celtics on Wednesday night

Tipoff is at 7:30 p.m. ET at the Scotiabank Arena in Toronto. Boston is favored by 14.5 points in the latest Celtics vs. Raptors odds, per SportsLine consensus, and the over/under is 229.5 points. Before entering any Raptors vs. Celtics picks, you'll want to see the NBA predictions from the model at SportsLine.

The Boston Celtics have been in a slump for nearly a month now, and Kristaps Porzingis isn't pleased with the team's effort amidst their struggles.

The Raptors, for their part, are doing a fantastic job positioning the team for lottery odds with just 2 wins in their last 10 contests.

The Toronto Raptors will look to keep up with the Boston Celtics on Wednesday: Where to watch, what to watch for, and more

Despite the struggles, both head coach Joe Mazzulla and star forward Jayson Tatum expressed confidence that the team can turn things around. After the tough overtime loss to the Hawks, Tatum was vocal about the team’s outlook moving forward.

The Boston Celtics surprisingly suffered a 13-point loss on Wednesday night against the Toronto Raptors, who rank last in the Atlantic Division, and