The Bills defense has faced an average of 24.5 attempts per game, the seventh-fewest faced by any defense. It’s not as simple to do as said, but the 49ers need to run the ball as much as they ...

The 49ers have reportedly granted Samuel permission to seek a trade, and the Buffalo Bills appear to be a reasonable ...

The San Francisco 49ers and head coach Kyle Shanahan have announced the team's latest coaching hires and title changes ahead ...

Watch Kansas City Chiefs quarterback Patrick Mahomes' best plays from his 3-touchdown game vs. the Philadelphia Eagles in Super Bowl LIX. Watch Philadelphia Eagles quarterback Jalen Hurts' best ...

The San Francisco 49ers could be looking to upgrade the corner position this offseason and they could look to April's draft ...

The San Francisco 49ers could soon be adding a minority stakeholder to the team's ownership group. According to Bloomberg, ...

As the 49ers prepare for the 2025 NFL Draft, we ran a mock simulator to see who PFF thinks the team will take, and a few may ...

"I was rooting for Josh Allen and the Bills honestly, just because I’m a fan of their game and the season that ... first Super Bowl victory over the 49ers in 2020 and their most recent last ...

With less than four minutes remaining, Allen launched a game-saving pass to Bills tight end Dalton Kincaid ... wins against the Eagles and the 49ers in the last two Super Bowls.

Here's what they'll need to focus on to get a win. The Buffalo Bills are set to host the San Francisco 49ers in a win-and-in game for the home team.

That said, this game still features a number of high-end offensive talent, so prop bets like anytime TDs remain well in play for Bills-49ers. Picking Anytime Touchdowns remains among the most ...