Potential Super Bowl opponents clash when the 49ers meet the Bills on Sunday Night Football. Our expert predictions expect a huge Bills win.

Get the latest update on Christian McCaffrey's injury: a potentially season-ending PCL injury that happened Week 13.

Josh Allen expertly navigated snow-topped turf, finding the end zone in a multitude of fashions and even receiving credit for catching his own touchdown pass in a Buffalo Bills thrashing of the San Francisco 49ers.

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” season-ending in the 49ers’ 35-10 loss to the Buffalo Bills on Sunday night.

San Francisco 49ers quarterback Brock Purdy is expected to play Sunday night against the Buffalo Bills, according to ESPN's Adam Schefter. Purdy was

San Francisco 49ers quarterback Brock Purdy official game status revealed for Week 13 primetime matchup against the Buffalo Bills.

It looks like the San Francisco 49ers might get their quarterback back under center in time for a Week 13 matchup with the Buffalo Bills. QB Brock Purdy injured his shoulder in Week 11 against the Seattle Seahawks and wound up missing the team’s blowout Week 12 loss to the Green Bay Packers.