Investigations into the reason why Shigella is enclosed within neutrophil vacuoles led Weinrauch and Zychlinsky to discover how the neutrophil can neutralize not only Shigella but also other ...

To assess the sizes of phagocytic vacuoles and their contents, 5 × 10 7 fresh human neutrophils were mixed with 5 × 10 8 IgG-opsonized S. aureus cells in a rapidly stirred chamber at 37 °C.

A key function of neutrophils is to attack and kill bacteria at sites of infection. Bacteria are phagocytosed and fusion of phagocytic vacuoles with neutrophil granules exposes the bacteria to a ...