Running back Christian McCaffrey refuses to buy into the doom and gloom surrounding the San Francisco 49ers since two straight losses sent them below .500.

The San Francisco 49ers announced they have waived wide receiver Ronnie Bell ahead of Sunday's game against the Buffalo Bills. The 49ers Communications

The Buffalo Bills will look to lock up a playoff spot in their Week 13 showdown with the San Francisco 49ers. Here are five storylines to watch.

The San Francisco 49ers have been hit hard by injuries throughout the season. Another player added himself to the list, but he’s continuing to play. All-Pro linebacker Fred Warner revealed that he’s been playing through a fracture ankle for weeks.

The San Francisco 49ers, despite careening toward the abyss of NFL mediocrity, still have a path to the postseason as they enter their Week 13 showdown against the Buffalo Bills. Yet, thanks to the rest of the NFC West's tussle with the .

The Buffalo Bills (9-2) bring a six-game winning streak into a matchup with the San Francisco 49ers (5-6) on Sunday, December 1, 2024 at Highmark Stadium. Buffalo is favored by a touchdown.NFL

Under head coach Kyle Shanahan, the San Francisco 49ers have spent years falling just inches short of the franchise’s sixth Lombardi Trophy. The Niners have mad

San Francisco has been up and down all season, but the Super Bowl hangover appears to be happening after the 49ers got destroyed by the Green Bay Packers. Granted Brock Purdy didn't play, but the 49ers didn't look like an NFC contender.

San Francisco 49ers linebacker Fred Warner says he has been playing through a fractured bone in his ankle since Week 4. Warner suffered the injury

We thought San Francisco was poised for a massive second-half run after the Week 9 bye with Christian McCaffrey back, but the 49ers haven't looked good over their last three contests.  It wasn't a surprise the 49ers fell to the Green Bay Packers on Sunday with so many key contributors out.

There's no two ways about it: the San Francisco 49ers are having a brutal season. Taking the field in Week 1 with sky-high expectations, what with eight-year head coach Kyle Shanahan having just taken his team to the Super Bowl last year,