The replication of potentially harmful adenoviruses can be significantly reduced in human cells in cell culture by using the so-called CRISPR-Cas9 system ("gene scissors"). This method, which is ...

A replication-competent adenovirus with tumor specificity was constructed by replacing the endogenous E1A promoter with a human telomerase reverse transcriptase promoter (TERTp) to control the ...

Both replication-incompetent and replication-selective adenoviruses are being developed for the treatment of cancer and other diseases. Concerns have been raised about the safety of intra-vascular ...

The adenovirus helper plasmid provides essential helper functions for AAV replication and packaging, whereas the AAV genome plasmid contains the therapeutic gene flanked by inverted terminal ...

Such vaccines have the potential to provide full protection from influenza infection by inhibiting viral replication. Adenovirus-based SARS-CoV-2 vaccine.

The vaccine is made up of two types of adenovirus. For one, a justification is presented for non-replication; for the other, it is not,” Mendes said. Meeting with Gamaleya Institute ...

Brazil’s regulators say they reviewed data indicating that there was replication-competent adenovirus (RCA) in every evaluated batch of the second Ad5-based dose of Sputnik V.

Adenovirus Replication Research (IMAGE) Saint Louis University. Caption. William Wold, Ph.D., is chair of molecular microbiology and immunology at Saint Louis University and senior author on ...

The tiny adenovirus protein known as ORF3 (shown in green) clears the way for adenovirus replication by creating "zip files" of genes that help the cell defend itself against the virus. O'Shea ...

Unlike the other two already approved in the U.S., the Pfizer and Moderna vaccines, the J&J "Janssen adenovirus-replication-deficient COVID-19 vaccine" only take one shot to gain effectiveness at ...