A replication-competent adenovirus with tumor specificity was constructed by replacing the endogenous E1A promoter with a human telomerase reverse transcriptase promoter (TERTp) to control the ...

The replication of potentially harmful adenoviruses can be significantly reduced in human cells in cell culture by using the so-called CRISPR-Cas9 system ("gene scissors") ...

However, some specialized cells, such as HEK 293, can facilitate the replication of E1-deficient adenoviruses by providing E1 functions in trans. What are the advantages of adenovirus-based vaccines?

Replication of ONYX-015 and wild-type Ad2 adenovirus in A2780 and drug-resistant derivatives The human ovarian cell line A2780, derived from an untreated patient, has wild-type p53 sequence and ...

Brazil’s regulators say they reviewed data indicating that there was replication-competent adenovirus (RCA) in every evaluated batch of the second Ad5-based dose of Sputnik V.

Anvisa’s president and the agency’s Management-General for Medications Gustavo Mendes said that the information on adenoviruses capable of replication could be found in the document submitted ...

J&J’s new Janssen COVID-19 vaccine only requires one shot and uses an “inactivated” adenovirus — which is known for causing the common cold — to do the work of staving off the coronavirus.

Because the adenovirus proteins involved in genome replication are distinct from those involved in particle assembly and genome packaging, the researchers reasoned focusing on this virus would ...

William Wold, Ph.D., is chair of molecular microbiology and immunology at Saint Louis University and senior author on a PLOS Pathogens paper that suggests a strategy to fight adenovirus in ...

The tiny adenovirus protein known as ORF3 (shown in green) clears the way for adenovirus replication by creating "zip files" of genes that help the cell defend itself against the virus. O'Shea ...