This problem can be partially remedied by using adenoviruses that have been genetically modified to be temperature-sensitive or replication-defective. AAV is not exclusively reliant on adenovirus ...

Adenoviral vectors will transduce a wide range of target cells resulting in high-level gene expression. They are non-integrating vectors so expression in dividing cells is progressively lost. First ...

One of the central challenges of rAAV production is the need for a ‘helper virus’ to facilitate replication within ... would first be infected with adenovirus, after which they would be ...

They show the vaccine’s package leaflet listing its ingredients, including “recombinant, replication-deficient chimpanzee adenovirus vector encoding the SARS-CoV-2 Spike glycoprotein”.