The 49ers host the Rams on Thursday Night Football. They’ve been losing running backs left and right, and now we’re awaiting ...

Niners running back Isaac Guerendo, who is listed as questionable with a sprained foot, insists he "feels good" for ...

The San Francisco 49ers running back spot has been a position of focus for fantasy football players throughout the season, ...

Isaac Guerendo became the team's starter last week and the rookie scored two touchdowns against the Bears, but his day ended ...

The San Francisco 49ers’ Week 15 injury report inspired a little bit of optimism on the health front as they enter a virtual ...

San Francisco 49ers rookie running back Isaac Guerendo is dealing with a foot injury and is listed as questionable for Week 15 against the Los Angeles Rams on T ...

The 49ers are playing on "Thursday Night Football" against the Rams. Will running back Isaac Guerendo be ready to play after ...

The San Francisco 49ers released their latest injury updates headed into the team's Week 15 "Thursday Night Football" matchup ...

San Francisco 49ers running back Isaac Guerendo has a foot sprain, per head coach Kyle Shanahan. 49ers HC Kyle Shanahan said ...

Status in question for Thursday ...

Most starters were on the sideline late in Week 14's lopsided win, while only one D-lineman played over 30 snaps.

San Francisco 49ers rookie running back Isaac Guerendo sustained a foot injury and is questionable to return in Sunday's ...